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What the research says
More than a carrier. And we cite every word.
People reach for Lemongrass Oil for far more than one thing. Here’s what the published studies actually found — graded honestly, each one linked.
11
uses studied
17
papers cited
0
hidden from you
What the published studies found
Early evidence · 2 studies
Burns/Wound Healing
Evidence for lemongrass oil in wound healing is entirely preclinical: a 2025 study showed gellan gum/collagen hydrogel membranes containing lemongrass oil accelerated full-thickness wound closure in rats (with antibacterial activity against S. aureus and E. coli, re-epithelialization, angiogenesis, and reduced IL-6/TNF-α), and a 2024 systematic review discusses lemongrass oil's potential for diabetic wound healing and tissue regeneration. No human clinical trials or RCTs for burns/wound healing were identified among the results reviewed.
In-vitro work shows lemongrass oil is fungicidal against Malassezia furfur (the yeast associated with dandruff), and a 2020 J Ethnopharmacology review reports that clinical studies using Cymbopogon citratus/C. flexuosus shampoo or cream formulations successfully treated dandruff. However, no RCTs were directly identifiable in the provided results (the result set was truncated), and the review authors themselves stress that larger in-vivo trials are still needed.
A 2024 systematic review of in vitro studies found lemongrass (Cymbopogon citratus) essential oil active against Candida biofilms on dental acrylic resin, in some comparisons outperforming nystatin, but all underlying evidence is laboratory-based. A 2025 preclinical wound-healing study with lemongrass oil hydrogels tested antibacterial (not antifungal) endpoints in rats, so no human clinical trials for fungal infection were identified in the visible results.
The available evidence consists of pharmaceutical formulation research and a narrative review, not clinical efficacy trials. The primary study (PMID 39069701) is an in-vitro emulgel formulation study in which lemongrass oil serves only as a penetration enhancer for the NSAID lornoxicam—not as the active anti-inflammatory agent—while the second (PMID 42522308) is a narrative review discussing lemongrass oil emulgels for rheumatoid arthritis without presenting original clinical data.
The visible search results (2 of 13 PMIDs were retrievable in the truncated output) contain no clinical trials of lemongrass for muscle pain. Evidence is limited to ethnobotanical documentation of traditional analgesic use (Ghana survey noting Cymbopogon citratus) and a toxicology study referencing beta-myrcene as 'the active principle of lemongrass tea' with reported analgesic properties — suggesting preclinical analgesic interest but no human efficacy data for muscle pain.
No human clinical trials of lemongrass for sleep/insomnia were identified; the available evidence is preclinical only, showing anxiolytic-like effects in mice mediated by the GABA-A/benzodiazepine receptor complex (PMID 21767622) with potentiation of drug-induced sleeping time only at high doses, and anesthetic/sedative effects in crustaceans (PMID 34486294).
The only retrievable study (PMID 39480758, PLoS One 2024) is a preclinical formulation study of a microemulsion hydrogel combining lemongrass essential oil with mango seed kernel extract, which showed in-vitro anti-inflammatory activity and anti-biofilm effects against Cutibacterium acnes comparable to adapalene/clindamycin gel. No human clinical trials, RCTs, or systematic reviews of lemongrass oil for acne were identified, and the combination formula prevents attributing effects to lemongrass alone.
The only directly relevant evidence is a 2023 in-vitro study (PMID 37247287) showing lemongrass oil (Cymbopogon citratus) reduced doxorubicin-induced cellular senescence and suppressed MMP-2 expression in fibroblast (NIH-3T3) and kidney (Vero) cell lines, leading authors to propose anti-aging potential. However, no human clinical trials, RCTs, or dermatological studies on wrinkles exist in the retrieved evidence.
The only relevant study is a narrative review of in-vitro antifungal testing showing essential oils (including Cymbopogon/lemongrass species) are active against Malassezia, a yeast that may exacerbate psoriasis; however, the clinical studies cited tested lemongrass formulations for dandruff and pityriasis versicolor, not psoriasis itself. No clinical trials directly evaluate lemongrass oil for psoriasis, so the connection remains indirect and unproven.
A single in vitro study (PMID 37228784) found lemongrass oil had the strongest killing effect against Demodex folliculorum mites—which are implicated in some rosacea cases—outperforming ivermectin 1% and metronidazole 0.75%. However, this was a laboratory mite-killing assay (10 mites per agent), not a rosacea treatment trial, and no human clinical studies of lemongrass oil for rosacea exist.
In vitro testing shows lemongrass essential oil potently inhibits Malassezia furfur (MIC 0.125% v/v), a yeast implicated in dandruff and seborrheic dermatitis, with activity attributed mainly to citral and citronellal. A single small, short controlled trial of a lemongrass oil hair tonic reported reduced dandruff, but no clinical studies directly evaluate lemongrass for scalp irritation itself.
